Monday October 16, 2017                                


7:00 – 12:00    Congress Registration – East and West Foyer


7:30 – 12:00 Young Investigators Pre-Symposium

Chairs: K. Ammann, USA; S. Gregory, Australia; T. Kaufmann, Germany; V. Merkle, USA; T. Siess, Germany/USA, T. Tsukiya, Japan


Young Investigator Presentations:


7:30 – 7:40        OxLDL Increases Susceptibility to Shear-Mediated Platelet Activation (77)

Shirzad Shir, University of Arizona, Tucson, AZ USA


7:40 – 7:50      Elevated Shear Associated with Mechanical Circulatory Support Devices Alters Membrane Fluidity and Lipid Composition in Exposed Platelets (118)

Alice Sweedo, University of Arizona, Tucson, AZ USA


7:50 – 8:00      Shear-Mediated Platelet Activation is Associated with Increased NOX4 Expression and Reactive Oxygen Species Generation (92)

            Michael Dicaro, University of Arizona, Tucson, AZ USA


8:00 – 8:10      Target-Specific Electrospinning: A Tissue Engineering Fabrication Technique for Creating Scaffolds Promoting Differential Vascular Cell Adhesion (119)

Daniel Palomares, University of Arizona, Tucson, AZ USA


8:10 – 8:20      Filling the Gap: The Relative Contribution of Proliferation vs Migration in Vascular Wound Healing (139)

Kaitlyn Ammann, University of Arizona, Tucson, AZ USA


8:20 – 8:30      Galvanotaxis: An Electroceutical Strategy for Improved Endothelialization of Cardiovascular Devices (115)

Kaitlyn Ammann, University of Arizona, Tucson, AZ USA


8:30 – 8:40      The Importance of Angle: Effect of Aorta – VAD Outflow Graft Anastomosis Angle on Platelet Activation (120)

Ryan Walk, University of Arizona, Tucson, AZ USA


8:40 – 8:50      In-Vitro Assessment of a Novel Polymeric Valve for Transcatheter Aortic Valve Replacement (87)

Oren Rotman/Jawaad Sheriff, Stony Brook University, Stony Brook, NY USA


8:50 – 9:00      Platelet Activity State Assay of A Heartmate II Patient With Recurrent Thrombosis (133)

  1. Tran, University of Arizona, Tucson, AZ USA


9:00 – 9:05       Acoustic Activation of Platelets: A Mechanism of Mechanical Platelet Activation – Relevant to VADs and Sleep-Disordered Breathing?  (Mini-Abs)

  1. Jerman, College of Medicine, University of Arizona, Tucson, AZ USA


9:05 – 9:15      The Six-Minute Walk Test Revisited: Stretchable Electronic Wearables Yield Motion Signatures of Heart Failure Patients (135)

  1. Mazumder, University of Arizona, Tucson, AZ USA


9:15 – 9:25      3D Printing for Pre-Procedural Planning of Ventricular Assist Device Placement in Adults With Congenital Heart Disease (134)

  1. Farooqi, Columbia University, New York, NY USA


9:25 – 9:35      Development of an Open-Source Research Platform to promote International Collaboration within the International Society for Mechanical Circulatory Support (74)

            Jo Pauls, ICETLAB, University of Queensland, Brisbane, Australia


9:35 – 9:45      Break


9:45 – 10:00    Growing an Investigative and Translational Career – S. Gregory, ICETLAB, University of Queensland, Brisbane, Australia


10:00 – 10:15 Opportunities/Career Paths for Young Engineers – V. Merkle, University of Arizona, Tucson, AZ USA


10:15 – 10:30  Unmet Needs, Opportunities, and Innovation – M. Slepian, University of Arizona, Tucson, AZ USA


10:30 – 10:45  Engineering and Medicine – Insights for Career Development from Industry and Academia: Mid-Career Perspectives – J. Barton, University of Arizona, Tucson, AZ USA


10:45 – 11:00  Academic Medicine and Research and the Clinical-Industry Interface “The Longview”– H. Eisen, Drexel University, Philadelphia, PA USA


11:00 – 11:15  A Career in Surgery, MCS, Insights for the Next generation – O. Howard “Bud” Frazier, Baylor/Texas Heart Institute, Houston, Texas USA


11:15 – 11:30  Going to the Dark Side: Pivoting from Academia to Industry – Bruce R. Rosengard, Johnson and Johnson Medical Devices, Boston, MA


11:30 – 11:45  Panel Discussion/Town Hall


11:45   Break



12:00 – 12:45 Opening Ceremony

Moderators:  M. Ono (J) – President, M. Slepian (USA) – Conference Chair


Welcome – M. Ono

Conference Strategy, Tactics and Details – M. Slepian

Limitations, Controversies and Gaps Theme

Innovation Methodology – approach to the meeting. – the “meeting mindset”

Writing Goal and other features

Dean’s Welcome – Charles Cairns MD– Dean, University of Arizona College of Medicine


12:45 – 1:15  KEYNOTE 1 LECTURE   Where is Advanced HF today and MCS?

Jeff Teuteberg – Stanford University, Stanford, CA USA


1:15 – 2:25    Scientific Session I

Controversy/Gap IAdvanced HF Issues /Patient selection

Moderators: A. El Banayosy (USA), S. Halleran (USA) and M. Ono (Japan)

1:15 – 1:30      Stepwise technology progression or definitive pump therapy – EP + PUMP vs PUMP?

  1. Halleran, Integris Health, Oklahoma City, OK USA

1:30 – 1:45      Technology advancement in cardiac resynchronization therapy for patients progressing to end-stage heart failure – P. Ryu, Abbott, Burlington, MA USA

1:45 – 2:00      Patient selection/Issue of the Less Sick Patient – INTERMACS IV-VII

  1. Horstmanshof, Integris Health, Oklahoma City, OK USA


2:00 – 2:15      HF Assessment and Scoring Systems

Moderators: A. El Banayosy (USA),  M. Slepian (USA) and N. Uriel (USA)

2:00 -2:15        HF and MCS Assessment and Scoring Systems – A. El Banayosy,

Integris Health, Oklahoma City, OK USA


Rapid Fire Abs

The Utility of Controlling Nutritional Status Score as A Prognostic Index In Patients With Left Ventricular Assist Device (25)

Akihito Saito, University of Tokyo, Japan


2:20 – 2:30   Panel discussion – E. Birks, H. Eisen, M. Hatano, U. Jorde, P. LePrince, B. Meyns

  1. Rame, N. Sweitzer


2:30 – 2:45      Coffee Break/Exhibits


2:45 – 3:55   Helmut Reul Young Investigator Awards

Moderators:   H. Schima (Austria) and M. Slepian (USA)


Platelet Lysis, Hemolysis, and Thrombin Generation under Ventricular Assist Device-Associated Hypershear Conditions (85)

Jawaad Sheriff, Stony Brook University, Stony Brook, NY USA


Normoxic But Not Hypoxic Extracorporeal Circulatory Support of The Fetus In An Artificial Womb Allows Normal Cardiac Development (95)

Carlo Bartoli, University of Pennsylvania, Philadelphia, PA USA


Update on Ghost Cells: From a Validated Principle to an Applicable Measurement Technique (111)

Malte Schops, Aachen University, Aachen, Germany


Coaxial Electrospun Scaffolds Seeded with Adipose-Derived Stem Cells for Cardiovascular Applications (123)

            Valerie Merkle, University of Arizona, Tucson, Arizona USA


Development and In-Vivo Testing of a Novel Passive Right Heart Assist System (28)

Tim Kaufmann, Enmodes GmbH, Aachen, Germany


Microfluidic Devices For Evaluating VAD-Specific Anti-Thrombotic Drug Efficacy Under Shear (36)

Annalisa Dimasi, Politecnico di Milano, Milan, Italy


Procoagulant Surface Exposure: A Promising “Early Bird” Marker of Shear-Mediated Platelet Activation Induced by Mechanical Circulatory Support (113)

            Yana Roka-Moiia, University of Arizona, Tucson, Arizona USA


3:55 – 4:05   The Honorable Jonathan Rothschild, Mayor of Tucson

– City Welcome and Opportunities


4:05 – 4:30 KEYNOTE 2 LECTURE   MCS of the Future – Biological Approaches

Doris Taylor, Texas Heart Institute, Houston, Texas USA


4:30 – 4:40 Coffee Break/Exhibits


4:40 – 5:40   Scientific Session II  

Controversy/Gap Issue II – Acute Support – Intermacs I

Temp Support to VAD vs. Direct VAD?    Criteria to go from Acute to Long Term VAD?   

Moderators:  P. Leprince (F), S. Nathan (USA), and A. Shiose (Japan)

4:40 – 4:45  Framing the Issues/Key Questions – A. El Banayosy, Integris Health, Oklahoma City, OK USA

4:45 – 5:00  Clinical Perspective I – B. Meyns, University Hospitals Leuven, Belgium

5:00 – 5:15  Clinical Perspective II – P. LePrince, H Pitié Salpétrière, Paris, France

5:15 – 5:30  Engineering Response – T. Siess – Abiomed, Danvers, MA USA

5:30 – 5:40  Panel Discussion    C. Bermudez, A. El Banayosy, M. Hatano, B. Meyns, S. Nathan,

  1. Rame, T. Siess, K. Toda


5:40 – 7:00   Scientific Session III

Bleeding and Hemolysis

Moderators: A. Redaelli (Italy), M. Slepian (USA) and G. Wieselthaler (USA)

5:40 – 5:55  Bleeding – The range of mechanisms – Carlo Bartoli, University of Pennsylvania, Philadelphia, PA USA

5:55 – 6:10  Bleeding and Angiogenesis – N. Uriel, University of Chicago, Chicago, IL USA

6:10 –  6:25  Hemolysis – U. Jorde/O. Saeed, Montefiore Medical Center, New York, NY USA


6:25 – 7:00 Rapid Fire Abs


Aspirin is associated with bleeding but does not modulate platelet function in patients with continuous-flow Left Ventricular Assist Device (69)

Federico Pappalardo, Universita Vita Salute, Milan, Italy


Significance of Cerebral Microbleeds in Patients with Continuous-flow LVAD (83)

Koichi Toda, Osaka University, Sumiyoshi-Ku, Osaka, Japan


Shear-Responsive Blood Coagulation Factors Related to Inhibition of Thrombosis (91)

Osamu Maruyama, AIST, Ibaraki Japan


Intensity of Hemolysis is Associated with Ischemic Stroke during Venous Arterial Extracorporeal Membrane Oxygenation Support (40)

Omar Saeed, Montefiore Medical Center, New York, NY USA


Energy-based Hemolysis Model on a Continuous Flow Pump using Large Eddy Simulation (45) Choon-sik Jun, Penn State College of Medicine, State College, PA USA


A New Hemolysis Prediction Model in Turbulent Blood Flow Based on Energy Dissipation

around Cells (54)

Jinjing Ji, Tsinghua University, Beijing, China


Large eddy simulation and hemolysis estimation of the FDA blood pump (108)

Peng Wu, Soochow University, Suzhou City, China


Soccer Game – Scrimmage with University of Arizona Soccer – “under the lights” at William David Sitton Field at University of Arizona Campus (Bus departs at 5:15pm for players)


7:00 Mixer/Hors d’oeuvres – Bill’s Grill Patio – Loews Ventana Canyon Resort









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